
A research at Massachusetts General Hospital, Boston has emphasized the key role of a protein “N-WASPâ€, in hair growth and hair loss. They analyze mice and observe the result difference in N-WASP deficient mice and normal mice. Analysis indicates that this protein has important role in growth of hair follicles and hence is an important component which is essential for cycling and generation of hairs.
Various human skin disorders are associated with disturb regulation of the cytoskeleton (the scaffolding that supports the cell). This is because many physiological processes in the skin, including wound healing and hair follicle cycling, involve cytoskeleton reorganization regulated by the proteins Cdc42 and Rac1.
A team of researchers, led by Scott Snapper, at Massachusetts General Hospital, Boston, has now determined that the protein N-WASP, which acts downstream of Cdc42 to regulate cytoskeleton reorganization, has a key role in skin function and hair follicle cycling by generating. They analyze mice having N-WASP deficiency.
Analysis of the mice indicated that N-WASP is critical for cells of the outer layer of the skin to proliferate and for hair growth but is dispensable for wound healing. The role of N-WASP in hair growth was found to be a result of its key role in hair follicle cycling and in the maintenance and differentiation of hair follicle progenitor cells. As further analysis indicated that N-WASP regulated the function of the gene regulatory protein β-catenin in cells of the outer layer of the skin from hair follicles, the authors suggest that N-WASP promotes β-catenin-dependent gene expression, thereby supporting the differentiation of hair follicle progenitor cells.
However, any potential solution or treatment for hair loss is exciting and we’ll be interested to follow any further studies of N-WASP use in humans.

















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